CO-FEROLIC Daily use - Film coated tablet
Box of 3 blisters of 10 film coated tablets;
Each film coated tablet contains:
Ferrous fumarate 182.04 mg (equivalent to 60 mg iron);
Folic acid 0.4 mg.
CO-FEROLIC Daily use is a combination of ferrous fumarate and folic acid which is available in film coated tablet. It is a brown coloured and round shaped film coated tablet with GLM embossing on one side and plain on other side.
Each CO-FEROLIC Daily use film coated tablet contains 182.04 mg ferrous fumarate (equivalent to 60 mg iron) and 0.4 mg folic acid.
PHARMACOLOGY AND MECHANISM OF ACTION
Iron is an essential constituent of hemoglobin, myoglobin, cytochrome C and respiratory enzyme systems. Ferrous absorbed from foods, ferrous from meat is the most efficient absorbed. Ferrous from meat is absorbed the most efficient. Ferrous is absorbed in the duodenum and proximal jejunum. Normally 0,5 – 1% mg daily of dietary Ferrous is absorbed but this can be increase if ferrous stores are low or ferrous requirement is low. Total iron absorptionincreases to 1 - 2 mg/day in menstruating women and canincrease to 3 - 4 mg/day in pregnant women. Iron requirement also increases ingrowing adolescents andchildren.
Folic acid is a vitamin B that is used in the prevention of folate-deficient state.
Iron and Folic acid are used together for the treatment and prevention of iron deficiency.
For the treatment of iron deficiency anemia.
For the of prevention of iron and folic acid deficiency in women of productive age, pregnant women and in the postnatal period for both lactating and nonlactating mothers, resulting from poor diet.
RECOMMENDED DOSE AND MODE OF ADMINISTRATION
The usual adult dose for the treatment of iron-deficiency anaemia: 1 tablet twice daily.
The usual adult prophylactic dose: 1 tablet daily.
* Mode of administration
It should be taken with food and a full glass of water.
Hypersensitivity to any ingredient of the formulation.
Esophageal atresia, gastrointestinal sac.
Children under 12 years of age and elderly.
SPECIAL WARNINGS AND PRECAUTIONS FOR USE
Patients should not exceed the recommended dosage, unless directed by the physician.
Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and folic acid antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides.
A high consumption of tea inhibits iron absorption.
Iron therapy can cause black or dark stools.
Ferrous fumarate should be used with caution in patients with haemochromatosis, haemoglobinopathies, or existing gastrointestinal diseases.
Use in pregnancy and lactation: Pregnant and breast-feeding women are advised not to exceed recommended dosage.
Effects on the ability to drive or operate machinery: CO-FEROLIC Daily use is expected to have no influence on the ability to drive and use machines.
INTERACTIONS WITH OTHER MEDICINE AND OTHER FORMS OF INTERACTION
Folate deficiency states may be produced by drugs such as antiepileptics, oral contraceptives, antituberculous drugs, alcohol, and folic acid antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides.
Compounds containing calcium and magnesium, including antacids and mineral supplements, bicarbonates, carbonates, oxalates, or phosphates, may impair the absorption of iron. Ascorbic acid and citric acid, may actually increase the absorption of iron.
Avoid taking iron coordination with ofloxacin, ciprofloxacin, norfloxacin.
Iron may chelatewithTetracyclines so that neither the antibiotic nor the iron is absorbed.
Iron may decrease the absorption of penicilamine, carbidopa/levodopa, methyldopa, quinolones, thyroid hormones and zinc salts.
Gastrointestinal disorders eg, nausea, vomiting, constipation or diarrhea and abdominal pain may occur. Allergic reactions have been reported.
Stop use and ask a doctor if unusual new symptoms occur.
Inform your physician in case of any adverse reaction related to drug use.
OVERDOSE AND TREATMENT
Symptoms: Information of overdosage is limited.
Treatment: There is no specific antidode. In the event of an overdose, symptomatic treament is mainly required.
DOSAGE FORMS AND PACKAGING AVAILABLE
Box of 3 blisters of 10 film coated tablets;
Box of 4 blisters of 25 film coated tablets.
Store at the temperature not more than 30oC, in a dry place, protect from light.
SPECIFICATION: BP 2012.
SHELF-LIFE: 24 months from manufacturing date.
KEEP OUT OF REACH OF CHILDREN
READ CAREFULLY THE LEAFLET BEFORE USE
FOR MORE INFORMATION, CONSULT YOUR PHYSICIAN
Manufactured by: GLOMED PHARMACEUTICAL Co., Inc.
Address: 35 Tu Do Boulevard, Vietnam – Singapore Industrial Park, Thuan An Town, Binh Duong Province.
Tel: 0650.3768824; Fax: 0650.3769095